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Figure 3 | Molecular Pain

Figure 3

From: Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCϵ pathway in dorsal root ganglion neurons

Figure 3

LPA potentiates TRPV1 currents time-dependently and dose-dependently. A: Representative TRPV1 current (right) potentiated by LPA in rat DRG neurons. DRG neurons were perfused with 0.01 μM LPA for 1 min before the second application of capsaicin (0.5 μM). The effect of LPA was wholly blocked by 10 μM capsazepine (cpz). B: 3 min after 0.01 μM LPA perfusion on DRG neurons, TRPV1 currents were highly increased (18 out of 26 cells, p < 0.001). C: After 0.01 μM LPA was perfused, TRPV1 currents were significantly increased, with maximal currents at 3 min, and decreased slowly to control level. D: Potentiation of TRPV1 currents by LPA at different concentrations. LPA increases TRPV1 currents dose-dependently. The currents were 3.21 ± 0.37 (1 μM, 8 out of 11 cells, p < 0.001), 2.09 ± 0.19 (0.1 μM, 6 out of 9 cells, p < 0.001), and 1.58 ± 0.09 (0.01 μM, 18 out of 26 cells, p < 0.001) folds higher than control currents respectively, with no effect by 0.001 μM LPA (data not shown).

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Molecular Pain

ISSN: 1744-8069

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