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Figure 6 | Molecular Pain

Figure 6

From: Involvement of lysophosphatidic acid in bone cancer pain by potentiation of TRPV1 via PKCϵ pathway in dorsal root ganglion neurons

Figure 6

LPA 1 receptor antagonist VPC32183 attenuates mechanical allodynia and thermal hyperalgesia in bone cancer rats. Injections of VPC32183 (i.t., 0.6 mM, 30 μl) or saline (30 μl) were made before cancer cell injection (D0), and D2, D4, D7, D9 after cancer cells injection. A: Alleviation of bone cancer-induced mechanical allodynia by LPA1 antagonist. Ipsilateral PWTs to stimuli of von Frey filaments were standardized with baseline. PWTs of Saline + Cancer rats decreased gradually 5 days after operation, significantly lower than that of Saline + Saline rats at D5 (p < 0.01), D7 (p < 0.01), D9 (p < 0.001), D11 (p < 0.001), D13 (p < 0.001) and D16 (p < 0.05). Compared with saline injection, administration of LPA1 antagonist VPC32183 increased PWTs at D7 (p < 0.05), D9 (p < 0.01) and D11 (p < 0.05) after cancer cell injection. B: Ipsilateral PWLs to radiant heating were increased by VPC32183 at D9 (p < 0.01) and D11 (p < 0.01) after cancer cell injection. #: (Saline + Cancer) vs. (Saline + Saline); *: (VPC32183 + Cancer) vs. (Saline + Cancer).

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