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Figure 3 | Molecular Pain

Figure 3

From: ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain

Figure 3

Hyperosmolarity Potentiates AGM-Evoked ASIC3 Activation. (A) Typical traces showing a lack of response to hyperosmolarity (600 mosmolkg-1 with mannitol, H-Osm), and currents induced by mild acid (pH 7.0), mild acid with hyperosmolarity (H-Osm + pH 7.0), AGM (1 mM), AGM (1 mM) with hyperosmolarity (H-Osm + AGM), AGM (1 mM) plus mild acid (pH 7.0 + AGM), and AGM (1 mM) with the combined mild acid and hyperosmolarity (H-Osm + pH 7.0 + AGM). (B) Pooled data as shown in (A). Data points are means ± S.E.M. of five to six measurements normalized to pH 7.0-induced current (dashed line). *p < 0.05, **p < 0.001, demonstrate the significant difference of current amplitude in the absence or presence of hyperosmolarity; & p < 0.05, demonstrates the significant difference of current amplitude in the absence or presence of mild acid (pH 7.0); @ p < 0.05, demonstrates the significant difference of current amplitude in the absence or presence of AGM (1 mM).

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