Figure 2
From: Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
CCL2 modulates action potential firing frequency in DRG neurons. (A) Current-evoked action potentials from a representative DRG neuron from CCI rat before during and after application of CCL2. rCCL2 evoked a concentration-dependent increase in firing during a depolarizing current step in DRG neurons. **p < 0.01, ***p < 0.001 vs vehicle. (B) Summary data showing the efficacy of AZ889 to block rCCL2-mediated excitation of neuropathic DRG neurons. *p < 0.05 vs vehicle.