Figure 4
From: Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
Mechanical and heat hyperalgesia in CCI rats. (A) Oral administration of AZ889 reverses mechanical and heat hyperalgesia in the CCI rats (tested 4 h after dosing). Oral administration of pregabalin reverses heat hyperalgesia in CCI rats (tested 1 h after dosing). (B) Intrathecal injection of AZ889 (1-30 nM/15 μL) reverses withdrawal latencies to heat stimulation of the affected paw in CCI rats (tested 15 min after dosing). Normalized values in parenthesis on top of the bar show mean % effect for each treatment. (C) Time course of the reversal of heat hyperalgesia after intrathecal injection of AZ889 (30 nmol/animal) in CCI rats (tested 15, 30, 60, 120 and 240 min after dosing). All panels, *p < 0.05, **p < 0.01, ***p < 0.001 vs vehicle (i.t. study: one-way ANOVA on the raw data and Holm-Sidak post hoc test). Normalized values in parenthesis on top of the bar show mean % effect for each time point.