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Figure 5 | Molecular Pain

Figure 5

From: Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Figure 5

Evoked neuronal spinal activity in CCI rats involves CCR2 signalling. (A) Innocuous brush-evoked activity of WDR neurons in CCI rats before, during and after spinal administration of 100 nM and 300 nM AZ889. *p < 0.05, ***p < 0.001 vs vehicle (two-way ANOVA and Bonferonni post hoc test). (B) Noxious pinch-evoked WDR neuronal activity before, during and after spinal administration of 100 nM and 300 nM AZ889 in CCI rats. **p < 0.01, ***p < 0.001 vs vehicle (two-way ANOVA and Bonferonni post hoc test). (C) Flexor alpha-motoneuron response to repetitive low frequency C-afferent fibre volleys to the sural nerve in vehicle- and AZ889-treated CCI rats. AZ889 i.v. infusion of 1 μmol/kg in 15 min preceded by a loading dose of 2.5 μmol/kg (2.4 μM plasma concentration) blocked wind-up response. ***p < 0.0001 vs vehicle.

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