Figure 6
From: Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
Neuronal and non-neuronal cells in spinal cord slices from CCI rats are responsive to CCL2 applications. Both neuronal (A, grey trace) and non-neuronal cells (B, grey trace) are responsive to 50 nM CCL2 application (black bar) in spinal cord slices from CCI rats. Average traces from 8 neuronal and 6 non-neuronal cells in 4 slices. Error bars show standard error. Pre-incubation of the spinal cord slices in AZ889 (100 nM) before (5 minutes), during and after the application of rCCL2 prevented the calcium response in both neuronal and non-neuronal cells (A and B, black traces).