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Table 2 Analgesic profile of AZ889 in CCI neuropathic rats

From: Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

 

Plasma-EC 50 (free # )

Brain-EC 50 (free # )

Effect at 48 μmol/kg

 

nM

nM

% (± SEM)

Mechanical

33

3.8

58 ± 16*

Thermal

80

6.1

60 ± 12*

  1. # Plasma protein binding = 82.6%, brain protein binding = 93.9%.
  2. * Significantly different (p < 0.001) from vehicle treated animals (n = 6-14)
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Molecular Pain

ISSN: 1744-8069

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