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Figure 1 | Molecular Pain

Figure 1

From: Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha

Figure 1

Effects of MPP on monosynaptic Aδ- or C-fiber eEPSCs in SG neurons. (A) Average traces of six consecutive Aδ-eEPSCs (stimulated at 0.2 Hz) before (left), during the treatment with MPP (10 μM, middle), and 5 min after washout (right) are shown. (B) Average traces of six consecutive C-eEPSCs (stimulated at 0.2 Hz) before (left), during the MPP treatment (10 μM, middle), and 5 min after washout (right) are shown. (C) Effects of MPP (10 μM) on monosynaptic Aδ- and C-fiber eEPSCs were obtained from a single neuron. Average traces of six consecutive eEPSCs (stimulated at 0.2 Hz) before (left), during the MPP treatment (middle), and 5 min after washout (right) are shown. (D) The MPP-induced increase in the amplitude of C-eEPSCs is more pronounced than that of Aδ-eEPSCs in SG neurons. Peak amplitudes of monosynaptic C-eEPSC and Aδ- fiber eEPSCs in the presence of MPP (10 μM) (n = 5 and 8 neurons, respectively) were analyzed. ** P < 0.01, *** P < 0.001 (paired t-test).

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Molecular Pain

ISSN: 1744-8069

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