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Figure 2 | Molecular Pain

Figure 2

From: Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha

Figure 2

MPP-induced increase in sEPSC frequency. (A) Traces of sEPSCs before (left) and during the MPP treatment (10 μM) (middle; 3 min after the beginning of MPP application), and after washout (right) are shown. (B) Cumulative distributions of the inter-event interval (left) and amplitude (right) of sEPSC before (black line), during the MPP treatment (red line) and washout (blue line) (n = 393, 339 and 321 sEPSC events over 1 min, respectively) are analyzed. (C) MPP only enhanced the frequency of sEPSC, but not their amplitude, in a dose-dependent manner. ** P < 0.01, *** P < 0.001 (paired t-test).

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