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Figure 10 | Molecular Pain

Figure 10

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 10

Blockade of mGluR1 has no effect on monosynaptic IPSCs in the arthritis pain model. (A, B) Individual traces of monosynaptic IPSCs recorded in one CeLC neuron at 0 mV show little variability in latency (10 sweeps) and follow high-frequency stimulation (20 Hz, 6 sweeps). Scale bars 50 pA, 10 ms. (C) NBQX (10 μM) had no significant effect on monosynaptic IPSCs (n = 3 neurons; P > 0.05, paired t-test). (D) LY367385 (10 μM) had no significant effect on monosynaptic IPSCs (n = 3 neurons; P > 0.05, paired t-test). (C, D) Individual traces show monosynaptic IPSCs before (Predrug) and during drug application. Stimulus intensity, 0.9 mA; scale bars, 50 pA, 10 ms. Bar histograms show means ± SE.

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Molecular Pain

ISSN: 1744-8069

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