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Figure 11 | Molecular Pain

Figure 11

From: Pain-related increase of excitatory transmission and decrease of inhibitory transmission in the central nucleus of the amygdala are mediated by mGluR1

Figure 11

Proposed circuitry. CeLC neurons receive direct excitatory input from the lateral-basolateral (BLA) nuclei that contains highly processed multimodal, including nociceptive, information [5, 8]. ITC cells provide inhibitory inputs that contact CeLC directly, acting on GABAA receptors, but also regulate glutamatergic inputs to the CeLC. Presynaptic mGluR1 inhibit GABAergic afferents. In the pain state, increased glutamatergic transmission to the CeLC activates not only postsynaptic mGluR5 but also presynaptic mGluR1 that inhibit GABAergic transmission. BLA, basolateral amygdala; ITC, intercalated cell masses; CeLC, latero-capsular division of the central nucleus of the amygdala; GABA

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Molecular Pain

ISSN: 1744-8069

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