Figure 2

Basal hyperalgesia and impaired sensitization after inflammation in transgenic mice. (A) Basal sensitivity to nociceptive stimulation in the indicated tests in wild type (wt) and transgenic L1 and L26 mice. (B) Inflammatory response in wild type (wt) and transgenic L1 mice 24 h after intraplantar injection of carrageenan. (C) Nociceptive thresholds in the plantar and the Von Frey tests before and at the indicated days after intraplantar injection of complete Freund's adjuvant (CFA) in wild type (wt) and transgenic L1 mice. * Refers to comparison with wild type and # refers to comparison with day 0. Statistically significant differences between groups (n = 10) were measured by One-way ANOVA with Bonferroni post test. * or #, P < 0.05; ** or ##, P < 0.01; ***, P < 0.001.