Table 1 Basic electrophysiological properties (current-clamp) and major traits for transient (IA) currents (voltage-clamp) of neurons from wild type and transgenic mice
Wild type | Transgenic | |
|---|---|---|
Current-clamp | ||
Number of neurons | 19 | 8 |
RMPa (mV) | -55.7 ± 0.8f | -53.9 ± 1.2 |
Rinb (MΩ) | 355 ± 20 | 387 ± 57 |
AP-Ac (mV) | 65 ± 2 | 68 ± 3 |
AP-Td (mV) | -39.7 ± 0.7 | -40.1 ± 1.3 |
Voltage-clamp | ||
Number of neurons | 18 | 7 |
Max current density (pA/pF) | 15.3 ± 3.3 | 14.5 ± 8.4 |
Time constant (ms) | 15.9 ± 1.5 | 15.7 ± 2.8 |
Activation; V50 e (mV) | -22.5 ± 2.1 | -20.1 ± 2.6 |
Activation; slope factor | 8.4 ± 0.7 | 6.5 ± 0.7 |
Inactivation; V50 e (mV) | -43.9 ± 1.7 | -40.1 ± 2.5 |
Inactivation; slope factor | -10.5 ± 1.0 | -9.5 ± 0.9 |