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Table 1 Basic electrophysiological properties (current-clamp) and major traits for transient (IA) currents (voltage-clamp) of neurons from wild type and transgenic mice

From: DREAM regulates BDNF-dependent spinal sensitization

  Wild type Transgenic
Current-clamp   
Number of neurons 19 8
RMPa (mV) -55.7 ± 0.8f -53.9 ± 1.2
Rinb (MΩ) 355 ± 20 387 ± 57
AP-Ac (mV) 65 ± 2 68 ± 3
AP-Td (mV) -39.7 ± 0.7 -40.1 ± 1.3
Voltage-clamp   
Number of neurons 18 7
Max current density (pA/pF) 15.3 ± 3.3 14.5 ± 8.4
Time constant (ms) 15.9 ± 1.5 15.7 ± 2.8
Activation; V50 e (mV) -22.5 ± 2.1 -20.1 ± 2.6
Activation; slope factor 8.4 ± 0.7 6.5 ± 0.7
Inactivation; V50 e (mV) -43.9 ± 1.7 -40.1 ± 2.5
Inactivation; slope factor -10.5 ± 1.0 -9.5 ± 0.9
  1. a resting membrane potential; b input resistance; c action potential amplitude; d action potential threshold; e voltage of half maximal activation or inactivation; f mean ± SEM.