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Figure 3 | Molecular Pain

Figure 3

From: Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B

Figure 3

The effect of BM-21 and thalassiolin B on nociception caused by formalin injection into the hind paw. A) No significant effect of BM-21 or amiloride was observed during the 1st-phase nociception, although indomethacin and thalassiolin B produced a significant reduction in the number of lickings. B) In the 2nd-phase, except for the lowest dose of the BM-21 (4 mg kg-1), all the drugs used produced a significant reduction in the number of lickings. The magnitude of the thalassiolin B action was similar to that of amiloride and apparently larger than that produced by 15 mg kg-1 indomethacin, but the difference was not significant (P = 0.302).

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Molecular Pain

ISSN: 1744-8069

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