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Figure 7 | Molecular Pain

Figure 7

From: Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B

Figure 7

The effect of thalassiolin B on the pH versus amplitude and steady state desensitization curve of the ASIC current. A) No significant influence of 100 μM thalassiolin B on the pH dependence of the ASIC current amplitude was found. B) The use of thalassiolin B also did not significantly modify the steady-state desensitization of ASIC currents. C) Analysis of the thalassiolin B effect as function of pH used to activate the current shows no significant correlation (P > 0.05). Line shows the linear regression (slope = 0.27); dotted lines show confidence intervals at P ≤ 0.05. D) Amiloride (30 μM) decreased the current 64 ± 4%. The coapplication of 30 μM amiloride and 100 μM thalassiolin B produced an additional nonsignificant 10.8 ± 3.8% decrease of the current (P ≥ 0.05 Student's t-test; thalassiolin B preapplied 20 s before coapplication of amiloride and thalassiolin B). Effects were fully reversible.

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Molecular Pain

ISSN: 1744-8069

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