Figure 6

AvCreERT2 expression or tamoxifen treatment (10 mg) does not affect acute nociceptive responses. A - Behavioural responses of AvCreERT2 and littermate mice to Aa) Rotarod (AvCreERT2 N = 13, littermate N = 11), Ab) von Frey (AvCreERT2 N = 13, littermate N = 11), Ac) Randall-Selitto (AvCreERT2 N = 8, littermate N = 8), Ad) Hargreaves' (AvCreERT2 N = 13, littermate N = 11), Ae) (AvCreERT2 N = 7, littermate N = 8) Af) Acetone (AvCreERT2 N = 8, littermate N = 8). No significant difference was found (t-test). Data are expressed as mean ± SEM. B - C57BL/6 mice received a five-day course of tamoxifen (2 mg/0.2 ml per day), or vehicle (0.2 ml per day). Responses to Ba) Rotarod (tamoxifen N = 12, vehicle N = 11) Bb) von Frey (tamoxifen N = 12, vehicle N = 11). Bc) Randall-Selitto (tamoxifen N = 6, vehicle N = 5) Bd) Hargreaves' (tamoxifen N = 12, vehicle N = 11) Be) 50 & 55°C Hot plate (tamoxifen N = 12, vehicle N = 11) Bf) Acetone (tamoxifen N = 12, vehicle N = 11). Animals were examined 7 days prior to tamoxifen treatment then 7 and 56 days after. No significant differences were found (Two-way repeated measures ANOVA). Data are expressed as mean ± SEM.