Figure 6

PICK1 knockout (KO) mice exhibit impaired neuropathic pain. L₅ SNL significantly increased paw withdrawal frequencies in response to 0.24 mN (low intensity; A) and 4.33 mN (moderate intensity; B) mechanical stimuli and significantly decreased paw withdrawal latency in response to heat stimulation (C) on the ipsilateral (ipsi), but not contralateral (contra), side in wild-type (WT) mice. PICK1 KO mice failed to exhibit any changes in paw withdrawal frequencies or latencies during the observation period. * P < 0.05, ** P < 0.01 vs the corresponding time points in PICK1 KO mice on the ipsilateral side.