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Figure 8 | Molecular Pain

Figure 8

From: Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1

Figure 8

L 5 spinal nerve ligation (SNL) does not induce GluR2 internalization in dorsal horns from wild-type (WT) mice. A, GluR2 levels in the cytosolic fraction from the ipsilateral dorsal horns of WT and PICK1 knockout (KO) mice at different time points after L5 SNL. Top: Representative Western blots. Bottom: Statistical summary of the densitometric analysis expressed relative to naïve (0) mice after normalization to corresponding β-actin. B, GluR2 levels in the synaptosomal membrane fraction from the ipsilateral dorsal horn of WT and PICK1 KO mice at different time points after L5 SNL. Top: Representative Western blots. Bottom: Statistical summary of the densitometric analysis expressed relative to naïve (0) mice after normalization to corresponding N-cadherin.

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