CPMs in P2Y
-/- mice exhibit decreased cold sensitivity. Sharp electrode recordings were made from WT and P2Y1-/- CPM afferents that were tested for their response to cold stimuli. A sample of the action potentials evoked by a cooling stimulus is shown (A). Compared to WT strains (grey), P2Y1-/- (black) CPM cells had lower cold thresholds (B; °C), but maintained a similar peak instantaneous frequency (C; Hz). Significance is indicated as p < 0.05 (*).