CPMs in P2Y
-/- mice exhibit decreased heat sensitivity. Sharp electrode recordings were made from WT and P2Y1-/- CPM neurons that were tested for their response to heat stimuli. A sample of the action potentials evoked by a heating ramp is shown (A). In comparison to WT mice (grey), the average thermal threshold of CPMs in mice lacking P2Y1 (black) showed decreased excitability in terms of a higher heat threshold (B; °C) and a lower peak instantaneous frequency (C; Hz). A heat ramp (D) from 31 to 52°C showed a significant reduction in the average spikes/second fired by CPMs from P2Y1-/- between the temperatures of 43-52°C. Significance is indicated as p < 0.05 (*).