Figure 1
From: Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C
Hyperexcitability of neuropathic DRG neurons to P2X activation and reversal by TTX. Representative traces of P2X current responses induced by 10 μM α,β-meATP and recorded from cultured rat DRG neurons. (A) Recordings in control (naïve) neurons (B) in neuropathic SNL neurons, and (C) in neuropathic SNL neurons in the presence of 1 μM TTX. (D) Current densities of peak P2X responses from naïve and neuropathic DRG neurons, in absence and presence of 1 μM TTX (N = 6-17, *** p < 0.0005).