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Figure 5 | Molecular Pain

Figure 5

From: Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C

Figure 5

Increased current amplitude and hyperpolarizing shift in voltage dependence of sensory sodium channels after neuropathic injury. (A) Representative current-voltage relationship traces of VGSC currents recorded from naïve and neuropathic DRG neurons. (B) Analysis of peak current amplitudes of voltage-gated sodium currents recorded at Vmax in naïve and neuropathic conditions (N = 4-5 for both groups, ** p < 0.005). (C) Sodium channel conductance was fitted with the Boltzman function (see Materials and Methods) from voltage-gated currents recorded in naïve and neuropathic neurons (N = 4-5).

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