Figure 7
From: Neuropathic Nav1.3-mediated sensitization to P2X activation is regulated by protein kinase C
Na v 1.3 activity is positively regulated by PKC. (A) Membrane potential depolarization induced Nav1.3-mediated sodium currents in Nav1.3-transfected CHO cells evoked using stimulus protocol described in methods section. (B) Current-voltage relationship of Nav1.3 activity in the presence and absence of 100 nM calphostin C (N = 6-8). (C) Voltage-dependent current density mediated by Nav1.3 channels in CHO cells in the presence and absence of 100 nM calphostin C (N = 6-8).