Figure 3
From: Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat
Chronic pancreatitis-induced significant increase of toll like receptor (TLR) 3 in the thoracic spinal dorsal horn. (A-C) Representative Western blot data showing the expressions of TLR2-4 in naïve, sham and 1-5 w following TNBS infusion. (D-F) statistical analysis on Western blot results. * P < 0.05 compared with that of naïve group. In naïve or sham operated rats, TLR 2-4 expressions in the thoracic spinal dorsal horn were at very low levels. After intrapancreatic infusion of TNBS, TLR 2 and TLR 4 were still at a very low level, compared with that of naïve and sham group. TLR 3 was significantly increased in the spinal cord, from 1 w after CP induction. TLR 3 was increased gradually and maintained at a very high level up to 5 w.