Figure 6
From: Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat
Intrathecal infusion of toll like receptor (TLR) 3 antisense oligodeoxynucleotide (ASO) on cytokine/chemokine expressions revealed by real-time PCR. Changes of (A) IL-1β, (B) TNF-α, (C) IL-6, (D) monocyte chemotactic protein-1 (MCP-1), and (E) cyclooxygenase 2 (COX-2) mRNA levels were determined in the T10 region of the dorsal spinal cord of pancreatic or sham rats. Significant increases of IL-1β, TNF-α, IL-6 and MCP-1, except COX-2, were observed in spinal cord of pancreatic rats. TLR3 ASO significantly attenuated up-regulation of IL-1β and MCP-1, but not TNF-α or IL-6. *, # P < 0.05 compared to sham-MO or TNBS-MO group, respectively.