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Figure 2 | Molecular Pain

Figure 2

From: Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?

Figure 2

Schematic representation of signaling pathways that modulate Na+ channels (Nav). The activation of G-protein-coupled receptors (GPCR) by their ligands activates adenylyl cyclase (AC) and phospholipase C (PLC), which produce cyclic adenosine monophosphate (cAMP) and diacylglycerol (DAG), respectively. cAMP then activates cAMP-dependent protein kinase (PKA), whereas DAG activates protein kinase C (PKC). Both PKA and PKC phosphorylate (P) the Na+ channel to regulate its function.

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Molecular Pain

ISSN: 1744-8069

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