Figure 2
From: Differential expression of microRNAs in mouse pain models
The effect of partial sciatic nerve ligation on miRNA expression in DRG and spinal cord dorsal horn. (A) Mice submitted to nerve lesion developed tactile stimulus-induced hypersensitivity at 1, 3, 7 and 14 days post-surgery (black bars) whereas sham-operated animals (white bars) showed no change on mechanical threshold. (B) In DRG, miR-206 (black bars) was downregulated at all time points investigated whereas miR-1 reduced relative expression (white bars) occurred only after the day 3 post-surgery. No significant change was detected for miR-16 (gray bars). (C) In spinal cord dorsal horn, there was no modification in the expression profile for any miRNA studied. Bars represent mean ± SEM. # p < 0.001 for nerve injured animals compared to sham-operated mice, n = 6 - 8 per group; Student's t-test. * p < 0.05, ** p < 0.01, and *** p < 0.001 for each miRNA expression in nerve injuried group compared to sham-operated control animals euthanized 24 h after surgery (time 0), n = 6 - 8 per group, Student's t-test.