Differential expression of microRNAs in mouse pain models

Molecular Pain

Table 1 Pain-related target genes predicted for miR-1, -16, -122, and -206 from in silico analysis.

Putative target	NCBI reference	microRNA	PicTar score	MicroCosm score	TargetScan score	Reference
Bdnf	NM 007540	1, 16, 122, 206	12.6, 13.9, x, 8.7	x, x, 15.9, x	-0.23, x, x, -0.23	[52–54]
Mapk3	NM 011952	1, 16, 122	x, 5.9, x	x, x, 15.5	-0.21, x, x	[55]
Calm2	NM 007589	1, 122, 206	5.6, 3.3, 6.6		-0.20, x, x	[56, 57]
Ngfr	NM 033217	1, 206			-0.06, x, -0.06	[58–60]
Pla2g4a	NM 008869	1, 206		17.4, 16.9	-0.34	[61–63]
Igf1	NM 010512	1, 206	3.1, 2.3		-0.47, x	[64, 65]
Trpc3	NM 019510	16		16.1		[66]
Oprd1	NM 013622	122			0.01	[67, 68]

Genes, and the corresponding regulatory miRNAs predicted according to PicTar (27), MicroCosm Target version 5 (internet available at http://www.ebi.ac.uk/enright-srv/microcosm), and TargetScan (28) databases. For each predicted gene the NCBI number, predicted microRNA, PicTar score, MicroCosm score, TargetScan score, and pain-related references are provided. Larger PicTar scores, higher MicroCosm scores, and more negative TargetScan scores indicate high-likelihood of encoding a target containing conserved 3' UTR sequences; x corresponds to non-identified target in the database.

ISSN: 1744-8069