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Figure 1 | Molecular Pain

Figure 1

From: 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

Figure 1

Paw withdrawal latency (PWL) to heat (a) and paw thickness (b) at baseline and on distinct days after CFA in wild-type mice (WT) and 5-HTT-/- mice (KO). On the operated side, the reduction of PWL to heat was attenuated after CFA in 5-HTT-/- mice compared with wild-type mice (a, **p < 0.01 compared with WT CFA). Paw thickness increased after CFA without differences between genotypes (b). n = 4 for each group.

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