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Figure 2 | Molecular Pain

Figure 2

From: 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

Figure 2

5-HIAA potentiated the reduction in paw withdrawal latency (PWL) to heat (a, ** p < 0.01 compared to vehicle injection, a) but not paw edema (thickness, b) caused by CFA in 5-HTT-/- mice. Note: all animals used here were 5-HTT-/- mice. n = 8 for each group. Arrow: 5-HIAA or vehicle (water with 0.1% sodium metabisulfate) injections.

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Molecular Pain

ISSN: 1744-8069

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