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Figure 3 | Molecular Pain

Figure 3

From: 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice

Figure 3

Pretreatment with p-CPA attenuated the CFA-induced reduction in paw withdrawal latencies (PWL)(a, ** p < 0.01 compared with NS+ CFA treatment) but not paw edema (b). Subsequent injection of 5-HIAA increased CFA-induced thermal hyperalgesia of p-CPA pretreatment mice (a, ## p < 0.01 compared with values at day 3) but had no effect on paw edema (n.s., b). Furthermore, methysergide, a non-selective antagonist of 5-HT receptors, could not antagonize the effects of 5-HIAA. p-CPA itself had no significant effect on baseline PWL (a) and paw thickness (b). Note: all animals used here were wild-type mice. n = 4~5 for each group. Arrow: 5-HIAA or vehicle (water with 0.1% sodium metabisulfate) injections.

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Molecular Pain

ISSN: 1744-8069

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