Table 1 Experimental design and main behavioral results
Genotype | Treatment | Route | Effect |
|---|---|---|---|
5-HTT +/+ | CFA | i.pl. | Hyperalgesia |
5-HTT -/- | CFA | i.pl. | Reduced hyperalgesia |
5-HTT -/- | CFA+5-HIAA | i.pl.+i.pl. | 5-HIAA restores CFA-induced hyperalgesia |
5-HTT -/- | CFA+Veh | i.pl.+i.pl. | Vehicle does not affect CFA-induced hyperalgesia |
5-HTT +/+ | NS+NS+Veh | i.p.+i.pl.+i.pl. | No change |
5-HTT +/+ | NS+CFA+Veh | i.p.+i.pl.+i.pl. | Hyperalgesia |
5-HTT +/+ | p-CPA+NS+Veh | i.p.+i.pl.+i.pl. | No change |
5-HTT +/+ | p-CPA+CFA+5-HIAA | i.p.+i.pl.+i.pl. | CFA-induced hyperalgesia is attenuated by p-CPA pretreatment; 5-HIAA restores hyperalgesia |
5-HTT +/+ | p-CPA+CFA+Methysergide/5-HIAA | i.p.+i.pl.+i.pl./i.pl. | Methysergide does not antagonize 5-HIAA induced hyperalgesia |
5-HTT +/+ | CFA+5-HIAA | i.pl.+i.pl. | 5-HIAA has no effect on CFA-induced hyperalgesia |
5-HTT +/+ | 5-HIAA | i.pl. | No change |