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Figure 10 | Molecular Pain

Figure 10

From: Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization

Figure 10

SFK inhibition prevents Ret phosphorylation. A) This representative Western blot demonstrates that the increase in p-Ret induced by 10 ng/mL GDNF is not prevented by either Scramble siRNA or c-Src siRNA. B) Densitometric analysis of three separate Western blots like that in A probing for p-Ret. C) This representative Western blot demonstrates that twenty minute exposure of DRG to 10 ng/mL ARTN increased p-Ret levels, and this increase was prevented by both Ret siRNA and the SFK inhibitor PP2. D) Densitometric analysis of three separate Western blots like that in A probing for p-Ret. Asterisks (*) indicate statistically significant differences between treatment conditions and the no treatment condition using an ANOVA with Dunnett's post hoc testing (p < 0.05).

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