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Figure 2 | Molecular Pain

Figure 2

From: (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice

Figure 2

Mechanical antinociceptive effects of (-)-pentazocine in wildtype, heterozygous, and homozygous MOP-KO mice. (-)-Pentazocine-induced alterations of %MPE in the hind-paw pressure test in wildtype (+/+; [A] closed circles, n = 8; [B] gray closed circles [male, n = 4], open circles [female, n = 4]), heterozygous (+/-; [A] closed triangles, n = 9; [B] gray closed triangles [male, n = 4], open triangles [female, n = 5]), and homozygous (-/-; [A] closed squares, n = 8; [B] gray closed squares [male, n = 4], open squares [female, n = 4]) MOP-KO mice under a cumulative dose-response paradigm. (A) Combined data of male and female mice. # p < 0.05, significantly different from wildtype mice. (B) # p < 0.05, significantly different from male wildtype mice; *p < 0.05, significantly different from female wildtype mice. Data are expressed as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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