Figure 3

Visceral chemical antinociceptive effects of (-)-pentazocine in wildtype, heterozygous, and homozygous MOP-KO mice. Writhing counts induced by 0.6% acetic acid (i.p.) with saline pretreatment in wildtype (+/+; [A] n = 9; [B] male [n = 5], female [n = 4]), heterozygous (+/-; [A] n = 8; [B] male [n = 8], female [n = 4]), and homozygous (-/-; [A] n = 8; [B] male [n = 4], female [n = 4]) mice, (-)-pentazocine pretreatment (10 mg/kg, s.c.) in wildtype (+/+; [A] n = 10; [B] male [n = 5], female [n = 5]), heterozygous (+/-; [A] n = 10; [B] male [n = 5], female [n = 5]), and homozygous (-/-; [A] n = 12; [B] male [n = 6], female [n = 6]) MOP-KO mice, and nor-BNI (10, 20 mg/kg, s.c.) and (-)-pentazocine (10 mg/kg, s.c.) pretreatment (10 mg/kg nor-BNI: [A] n = 11; [B] male [n = 5], female [n = 6]; 20 mg/kg nor-BNI: [A] n = 11; [B] male [n = 6], female [n = 5]) in homozygous MOP-KO mice. (A) Combined data of male and female mice. (A, B) ^### p < 0.001, significantly different from saline pretreatment; ^$ p < 0.05, significantly different from wildtype mice. *p < 0.05, significantly different from (-)-pentazocine-pretreated homozygous MOP-KO mice. Data are expressed as mean ± SEM.