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Figure 4 | Molecular Pain

Figure 4

From: (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice

Figure 4

Somatic chemical antinociceptive effects of (-)-pentazocine in wildtype, heterozygous, and homozygous MOP-KO mice. Time-course of (A) and cumulative (B, C) nociceptive scores of formalin-induced nociceptive behavior with saline pretreatment in wildtype (+/+; male [n = 5], female [n = 6]), heterozygous (+/-; male [n = 5], female [n = 5]), and homozygous (-/-; male [n = 5], female [n = 5]) mice and (-)-pentazocine pretreatment (10 mg/kg, s.c.) in wildtype (+/+; male [n = 5], female [n = 5]), heterozygous (+/-; male [n = 5], female [n = 5]), and homozygous (-/-; male [n = 5], female [n = 7]) MOP-KO mice. (A, B) Combined data of male and female mice. (A-C) # p < 0.05, ## p < 0.005, ### p < 0.001, significantly different from saline pretreatment. (B, C) *p < 0.05, **p < 0.005, ***p < 0.001, significantly different from wildtype mice. Data are expressed as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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