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Figure 5 | Molecular Pain

Figure 5

From: (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in μ-opioid receptor knockout mice

Figure 5

Binding properties and agonist effects of (-)-pentazocine on human opioid receptor subtypes. (A) Binding properties of (-)-pentazocine for displacement of specific binding of 2 nM [3H]DAMGO, 2 nM [3H]DPDPE, and 3 nM [3H]U69593 to membranes of MOP/CHO cells (closed circles, n = 4), DOP/CHO cells (closed squares, n = 4), and KOP/CHO cells (closed triangles, n = 4), respectively. Data are expressed as mean ± SEM. (B) Agonist effects of (-)-pentazocine on forskolin-stimulated cAMP production in MOP/CHO cells (closed circles, n = 4), DOP/CHO cells (closed squares, n = 4), and KOP/CHO cells (closed triangles, n = 4). Intracellular cAMP levels in the cells incubated with 10 mM forskolin alone served as controls (100%). Data are expressed as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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