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Figure 2 | Molecular Pain

Figure 2

From: Peripheral effects of morphine and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling

Figure 2

Reversion of the antiallodynic effects of morphine. Reversal of the effects of morphine (400 nmol) on the mechanical (A) and thermal (B) allodynia induced by CCI in the ipsilateral paw of WT mice, at 21 days after CCI, by the subplantar co-administration of a selective MOR antagonist (CTAP; 108.7 nmol) or a peripheral non-selective opioid receptor antagonist (NX-ME; 42.6 nmol). The effects of the subplantar administration of vehicle, CTAP (108.7 nmol) or NX-ME (42.6 nmol) administered alone are also shown. Data are expressed as mean values of maximal possible effect (%) for mechanical allodynia and inhibition (%) for thermal allodynia ± SEM (5-6 animals for each group). For each test, * represents significant differences compared to the other groups (P < 0.05; one way ANOVA, followed by the Student Newman Keuls test).

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Molecular Pain

ISSN: 1744-8069

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