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Figure 1 | Molecular Pain

Figure 1

From: Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

Figure 1

Responses of mechano-C fibre nociceptors following peripheral administration of galanin in rat and mouse. Subcutaneous injections of galanin were administered locally into the receptive field of mechanical nociceptive C-fibre afferents in intact naïve rodents. [A] 100 nM galanin significantly reduced mechanical activation thresholds in rats compared to vehicle (one way ANOVA with post-hoc Bonferroni multiple comparison test, *p < 0.05, n = 4). [B] 10 uM galanin, significantly increased mechanical thresholds in rats compared to vehicle (one way ANOVA with post-hoc Bonferroni multiple comparison test, *p < 0.05, n = 4). [C] 10 uM galanin significantly increased mechanical activation thresholds in mice (one way ANOVA, *p < 0.05, n = 5) and [D] 10 uM galanin significantly attenuated mechanically evoked activity to a 2 g von Frey hair in mice (one way ANOVA with post-hoc Bonferroni multiple comparison test, * p < 0.05, n = 5).

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