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Figure 4 | Molecular Pain

Figure 4

From: Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia

Figure 4

Mechanical responses of C fibre nociceptors following GalR2 activation. Subcutaneous injections of Gal2-11 were administered locally into the receptive field of mechanical nociceptive C-fibre afferents in intact naïve rats. [A] 100 nM Gal2-11 significantly decreased activation thresholds (one way ANOVA with post-hoc Bonferroni multiple comparison test, * p < 0.05, n = 4), and [B] facilitated mechanically evoked activity to a 4 g von Frey hair (one way ANOVA with post-hoc Bonferroni multiple comparison test, * p < 0.05, n = 4). [C] 10 uM Gal2-11 significantly increased mechanical activation thresholds (one way ANOVA with post-hoc Bonferroni multiple comparison test, * p < 0.05, n = 5), and [D] significantly decreased mechanically evoked activity to a 4 g von Frey hair (one way ANOVA with post-hoc Bonferroni multiple comparison test, *p < 0.05, n = 5).

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