Figure 3
From: Hypotonicity modulates tetrodotoxin-sensitive sodium current in trigeminal ganglion neurons
Role of PKA and PKC system in hypotonicity-induced increase of TTX-S current. A. In the presence of PKC antagonist BIM or staurosporine, hypotonicity-induced increase of TTX-S current was markedly blocked from 37.74 ± 2.12% to 14.55 ± 3.09% (unpaired t-test, P < 0.05) and to 13.17 ± 5.10% (unpaired t-test, P < 0.05), respectively. B. Hypotonicity-induced response was not affected by PKA antagonists and TTX-S current was increased 35.63 ± 1.17% (unpaired t-test, P > 0.05) and 36.09 ± 3.47% (unpaired t-test, P > 0.05) by hypotonicity in the presence of H-89 or KT5720, respectively.