Figure 2

Oxaliplatin (OHP) induces mechanical and cold allodynia but not heat hyperalgesia. (a) Mice treated with oxaliplatin 3.5 mg/kg/iv twice weekly (n = 8) had a significant decrease in mechanical threshold from baseline and compared to naïve mice (n = 8) that started after the first week of treatment and persisted for at least four weeks. **p < 0.001 vs. baseline, Friedman Test; #p < 0.001 vs. naïve, Mann Whitney U Test. (b) Mice treated with oxaliplatin 3.5 mg/kg/iv twice weekly (n = 8) had a significant increase in cold threshold from baseline and compared to naïve mice (n = 8) that started after the first week of treatment and persisted for at least four weeks. *p < 0.01 vs. baseline, ANOVA with Repeated Measures; #p < 0.05 vs. naïve, Student's T Test. (c) Mice treated with oxaliplatin 3.5 mg/kg/iv twice weekly (n = 8) had no change heat threshold from baseline and were not different from naïve mice throughout the duration of the experiment. P > 0.05 vs. baseline, ANOVA with Repeated Measures; p > 0.05 vs. naïve, Student's T Test.