Figure 4From: Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats Effect of PEA on λ-carrageenin-induced hyperalgesia. Mechanical allodynia was evaluated by von Frey filament as (A) a target force both centrally and externally to granulomatous tissue and as (B) the frequency of withdrawals induced by 10 consecutive applications of the same von Frey filament. Results are expressed as mean ± SEM of 3 experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs. saline; °p < 0.05, °°p < 0.01, °°°p < 0.001 vs λ-carrageenin alone.Back to article page