Figure 7

Effects on alkylamide on pain behaviour. A. Quantification of the number of flinching and licking behavior after intradermal injection of 2 ul IBA (0.1 or 1%) or vehicle in the rat hindpaw. The mean number of counts over a period of 10 min is shown (n = 11-14 animals per group). *p < 0.05; **p < 0.01 vs. vehicle injection. B. Time-course of flinching behavior. Number of counts per minute is shown for each group. IBA or vehicle was injected at time 0. C. Time-course of licking behavior. Number of counts per minute is shown for each group. D. Mechanical sensitivity to application of von Frey hairs. 50% mechanical threshold was measured using the up-down method before and after injection of vehicle or 1% IBA in the rat hindpaw (n = 8 animals in each group). ***p < 0.001 vs. basal threshold; ^###p < 0.001 vs. vehicle injection.