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Figure 2 | Molecular Pain

Figure 2

From: Local activation of cannabinoid CB1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents

Figure 2

Effects of cyclophosphamide and AZ12646915 on the bladder compliance and firing threshold of the afferent fibers. A and B) Compliance of the bladder calculated as the volume infused to reach 40 mm Hg in normal (29 mice) and cyclophosphamide (CYP) (19 mice) pooled groups (A) and pre- versus post-administration of AZ12646915 in CYP mice (7 mice) (B). C and D) Firing threshold (mm Hg) of afferent fibers responding to bladder filling in normal (146 fibers, 52 mice) and CYP (63 fibers, 19 mice) pooled groups (C) and pre and post AZ12646915 in CYP mice (29 fibers, 7 mice). Results are mean ± SEM. Normal versus CYP analyzed with t-test (*** P < 0.001) (A and C). Pre- versus post-drug analyzed with paired t-test (B and D).

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Molecular Pain

ISSN: 1744-8069

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