Figure 8

Voltage-dependent activation and fast-inactivation for sodium currents in mouse OSN. (A), sodium currents were evoked by 100 ms depolarizing pulses from -90 mV to +50 mV in steps of 5 mV every 5 s from a holding potential of -100 mV. (B), Normalized peak current-voltage relationship. (C), The inward current was completely blocked by 300 nM TTX. (D), Voltage dependence of activation and steady-state fast-inactivation. To measure steady-state fast-inactivation, sodium currents were elicited by 500 ms prepulses from -160 mV to -20 mV stepped by 10 mV and followed by a 40 ms depolarizing pulse to -20 mV from a holding potential of -100 mV. The activation and fast-inactivation curves were obtained from a Boltzmann fit to the normalized conductance.