Figure 6
Pre-injury administration of 2ccPA (i.t.) prevents development of neuropathic pain. Neuropathic pain was induced by partial sciatic nerve injury in mice. 2ccPA (10 or 100 nmol/5 μL i.t.) was injected at 30 min prior to nerve injury. The threshold was measured on days 3, 5, and 7 after nerve injury, using the thermal withdrawal (A) and paw-pressure (B) tests. All data represent the mean ± S.E. from 3-6 individual mice per group. *P < 0.05; significantly different from the control response by Tukey's multiple comparison tests.