Figure 8

Repeated administration of 2ccPA (i.v. or i.t.) induces analgesia against established mechanical allodynia in neuropathic pain mice. Vehicle or 2ccPA (10 mg/kg i.v.) was daily injected for 8 days, starting 7 days after injury (A). The threshold in the paw pressure test was measured at 30, 60, 90, 120, 150, and 180 minutes after 2ccPA application (i.t. or i.v.) on the eighth day (B and C). Quantitative analyses with 2ccPA (i.t. or i.v.) were performed with the area under the curve (AUC) (D). AUC data represent increased thresholds by subtracting the thresholds before injection in vehicle-treated mice. All data represent the mean ± S.E. from 3-6 individual mice per group. *P < 0.05 indicates significant difference from the vehicle response by Tukey's multiple comparison test.