Figure 4
From: TRPV3 and TRPV4 ion channels are not major contributors to mouse heat sensation
Effect of TRPV1 antagonism on acute and inflammatory heat-evoked nociceptive behavior of TRPV3/TRPV4 double knockout mice on the C57BL6 background. (A) Effect of TRPV1 antagonist (JNJ-17203212, 40 mg/kg, i.p., open symbols, n = 7 per genotype) or vehicle (filled symbols, n = 7 per genotype), administered at the indicated time, on tail withdrawal latencies from a 50°C water bath in naïve wild-type (squares) and TRPV3/TRPV4 double knockout (circles) mice. (B) Ipsilateral paw withdrawal latencies to radiant heat in naïve wild-type (filled bars) and TRPV3/TRPV4 double knockout (open bars) mice prior to and 48 hr after intraplantar injection of complete Freund's adjuvant (CFA, 50% in saline) in the left hindpaw (10 μl) (wild-type, n = 30; TRPV3/TRPV4 double knockout, n = 32). (C) Effect of TRPV1 antagonist (JNJ-17203212, 40 mg/kg, i.p., open symbols) or vehicle (filled symbols), on post-CFA paw withdrawal latencies in the wild-type (squares, n = 15 per treatment) and TRPV3/TRPV4 double knockout (circles, n = 16 per treatment) mice shown in panel (B). Data shown represent mean ± SEM.